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胃食道疾病风险和吸入暴露系统性审查和元分析
Daniel Hyun Kim1, Sanjiti Podury1, Aida Fallah Zadeh1
1Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, New York University Grossman School of Medicine (NYUGSoM), New Bellevue, 16N Room 20 (Lab), 462 1st Avenue, New York, NY, 10016, USA.
吸烟和空气污染等吸入暴露会显著增加上部胃肠道疾病的风险,包括食道炎,GERD,胃潰瘍和癌症. 然而,没有发现与巴雷特有任何显著联系.
科学领域:
- 环境健康 环境健康
- 胃肠病学 胃肠病学
- 公共卫生 公共卫生
背景情况:
- 空气污染的增加和吸入剂的使用与环境暴露相关的疾病有关.
- 研究越来越多地表明,环境暴露会影响呼吸道以外的系统,包括胃肠道系统.
- 了解吸入对上胃肠道健康的影响至关重要.
研究的目的:
- 系统地审查和分析吸入暴露与上部胃肠道疾病风险之间的关联.
- 更新当前关于环境因素与胃肠道健康之间的联系的知识.
- 为各种与吸入暴露相关的上部胃肠道疾病提供综合估计.
主要方法:
- 来自PubMed和Web of Science的研究的系统审查和元分析.
- 资格标准用于确定有关吸入暴露和上部肠道疾病的相关研究.
- 偏差风险评估和敏感性分析以确认发现.
主要成果:
- 在吸入暴露 (吸烟,颗粒物) 和食道炎 (OR 1.32),GERD (OR 1.71),胃潰瘍疾病 (OR 1.21),食道癌 (OR 1.83) 和胃癌 (OR 1.71) 之间发现了显著的关联.
- 对于巴雷特食道 (OR 0.93) 没有观察到任何显著的关联.
- 大多数纳入的研究质量良好,敏感性分析支持了主要发现.
结论:
- 吸入性暴露与几种上部胃肠道疾病的风险增加显著相关.
- 需要进行公共卫生干预,以解决吸入对胃肠道健康的影响.
- 需要进一步的研究来阐明这种相互作用背后的机制.
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