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Updated: Sep 17, 2025

Monitoring Activation of the Antiviral Pattern Recognition Receptors RIG-I And PKR By Limited Protease Digestion and Native PAGE
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通过抑制PKR介导的抗病毒应激颗粒的形成,TRBP调节RLR信号

Koji Onomoto1, Monami Sakai1, Miyu Watanabe1

  • 1Division of Molecular Immunology, Medical Mycology Research Center, Chiba University, Chiba, 260-8673, Japan.

Scientific reports
|July 1, 2025
PubMed
概括

TAR-RNA结合蛋白 (TRBP) 抑制了抗病毒应激颗粒 (avSG) 的形成,抑制了I型干扰素 (IFN) 的表达. TRBP通过抑制PKR激活来负面调节RLR信号,这是avSG组装的一个关键步骤.

关键词:
抗病毒天生的免疫力.国际货币基金组织 IFN IFN在RLRLR中,使用RLR是非常重要的.压力颗粒是一种压力颗粒.在TRBP中,您可以使用TRBP.

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