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怀孕和产后双极性障碍的管理:临床医生指南
Veerle Bergink1,2, Mariella Suleiman3,4, Mary-Anne Hennen3,5
1Department of Psychiatry, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, Room L4-34, New York, NY, 10029, USA. Veerle.bergink@mssm.edu.
CNS drugs
|July 2, 2025
概括
在怀孕和产后期间治疗双极性障碍 (BD) 需要仔细选择药物. 建议使用,而应避免使用烯酸盐和碳胺,以防止复发和保护儿童.
科学领域:
- 围产阶段精神病学 围产阶段精神病学
- 药理学 药理学是指药理学的学科.
- 妇女健康 妇女健康
背景情况:
- 怀孕期间双极性障碍 (BD) 的管理是复杂的,因为药物逐渐减少和高产后复发风险.
- 围产期对患有BD的女性构成独特的挑战,影响治疗的坚持和安全.
- 现有的围产期BD治疗研究往往缺乏对母亲和儿童的全面有效性和安全性数据.
研究的目的:
- 审查常见双相情感障碍治疗的围产期疗效和对儿童的潜在不良影响.
- 为患有BD的孕妇和产后妇女提供基于证据的药物管理建议.
- 突出结构化的围产期复发预防计划的重要性.
主要方法:
- 关于双相情感障碍的围产期治疗方法的科学文献的叙事综述.
- 对常见药物的分析,包括,拉莫特里金,其他抗药,抗精神病药,抗抑郁药和睡眠辅助药.
- 评估产性风险和对婴儿发育的影响.
主要成果:
- 仍然是BD治疗生殖年龄妇女的黄金标准,尽管使用量下降.
- 瓦尔酸盐和卡巴马西平具有较高的致病风险,应该避免在生育年龄的妇女使用.
- 适当的药理预防可显著降低患有BD的女性产后复发风险.
结论:
- 一个协作性的,书面的围产期双极性复发预防计划至关重要.
- 该计划应包括维持治疗,分娩,产后药物,食,睡眠策略和复发识别.
- 谨慎的药物管理,优先考虑安全性和有效性,对于患有BD的围产期妇女至关重要.
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