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Updated: Sep 17, 2025

Strand-Specific Analysis of Proteins at Replicating DNA Strands by Enrichment and Sequencing of Protein-Associated Nascent DNA Method
08:53

Strand-Specific Analysis of Proteins at Replicating DNA Strands by Enrichment and Sequencing of Protein-Associated Nascent DNA Method

Published on: May 2, 2025

490

通过VCP/p97从染色质中提取DNA聚合酶α/原酶,在不被干扰的DNA复制过程中限制ATR激活

Sara Rodríguez-Acebes1, Rodrigo Martín-Rufo2, Alicia Gómez-Moya2

  • 1DNA Replication Group, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.

Nature communications
|July 2, 2025
PubMed
概括

AAA ATPase VCP/p97通过控制染色体上的DNA聚合酶α/Primase复合体 (POLA/PRIM) 来限制DNA复制. 抑制VCP/p97激活ATR和CHK1,导致细胞循环停止.

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