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相关概念视频

Exercise and Muscle Performance01:27

Exercise and Muscle Performance

1.6K
Exercise induces a range of adaptations in muscle tissue, depending on the type and duration of activity. Such physical training can be broadly categorized into two types: endurance exercises and resistance exercises.
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
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相关实验视频

Updated: Sep 17, 2025

A Simple and Inexpensive Running Wheel Model for Progressive Resistance Training in Mice
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肌肉Rev-erb控制了老鼠对慢性炼的时间依赖性适应.

Jidong Liu1,2, Fang Xiao3,4, Abhinav Choubey2

  • 1Department of Endocrinology and Metabolism, Qilu Hospital of Shandong University, Jinan, Shandong, 250101, China.

Nature communications
|July 2, 2025
PubMed
概括
此摘要是机器生成的。

睡前炼提供了比起起床后炼更大的肌肉和葡萄糖益处. 肌肉是指肌肉中的肌肉.

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Activating Autophagy by Aerobic Exercise in Mice
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Activating Autophagy by Aerobic Exercise in Mice

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Last Updated: Sep 17, 2025

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科学领域:

  • 时间生物学 时间生物学
  • 运动生理学 运动生理学
  • 代谢健康 代谢健康

背景情况:

  • 慢性炼训练的最佳时间尚不清楚.
  • 肌肉性能和训练适应性的日间变化尚未得到充分理解.
  • 生物钟在肌肉功能和运动反应中的作用需要进一步研究.

研究的目的:

  • 在小鼠中确定一天中最佳时间进行低强度跑步机训练.
  • 阐明肌肉性能和训练适应性的日间变化的潜在机制.
  • 研究肌肉特异性昼夜钟基因Rev-erbα/β在这些过程中的作用.

主要方法:

  • 在小鼠中,低强度,低体积的跑步机训练.
  • 肌肉收缩性能和全身葡萄糖耐受性评估.
  • 在Rev-erbα/β (Rev-MKO) 小鼠的肌肉特异性淘汰中.
  • 多组和代谢测量.

主要成果:

  • 睡觉前的跑步机训练比起起床后的训练更能提高肌肉性能和耐葡萄糖.
  • 基线肌肉强度较高,而耐力在睡眠前比起醒来后更低.
  • 肌肉特异性的Rev-erbα/β淘汰消除了训练反应和基线肌肉功能的日间变化.
  • 在睡眠之前,Rev-erb抑制脂肪酸氧化,促进碳水化合物代谢.

结论:

  • 由Rev-erb调节的肌肉自主昼夜时钟,决定肌肉功能和训练适应性的日间变化.
  • 食和运动行为并不是这些日间变化的主要驱动因素.
  • 这些发现对在代谢障碍和体育医学中优化运动时间有重大意义,特别是在Rev-erb激动剂中.