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Updated: Sep 17, 2025

Heterogeneity Mapping of Protein Expression in Tumors using Quantitative Immunofluorescence
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Heterogeneity Mapping of Protein Expression in Tumors using Quantitative Immunofluorescence

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个人内表观遗传异质性是晚期前列腺癌的表型亚型的基础

Kei Mizuno1, Sheng-Yu Ku1, Varadha Balaji Venkadakrishnan1

  • 1Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

Nature communications
|July 2, 2025
PubMed
概括

这项研究揭示了表观遗传变化如何驱动抵抗割的前列腺癌 (CRPC) 和神经内分泌前列腺癌 (NEPC) 的异质性. 整合DNA甲基化,RNA测序和基因素标记,确定了晚期前列腺癌中转录重编程的机制.

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X-chromosome...
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