大脑不对称度的纵向变化跟踪生活方式和疾病
Karin Saltoun1,2, B T Thomas Yeo3,4,5,6,7,8, Lynn Paul9
1The Neuro - Montreal Neurological Institute (MNI), McConnell Brain Imaging Centre, Department of Biomedical Engineering, Faculty of Medicine, School of Computer Science, McGill University, Montreal, Canada.
Nature communications
|July 2, 2025
概括
大脑不对称性在成年期间发生变化,这表明神经可塑性. 这些大脑变化与生活方式,退休和疾病风险相关,挑战了成年大脑静态组织的概念.
科学领域:
- 神经科学是一个神经科学.
- 人类生物学 人类生物学
- 脑部成像 脑部成像
背景情况:
- 人类大脑组织表现出显著的左右不对称,特别是在语言和情绪处理等独特能力方面.
- 以前的理解表明大脑不对称性在很大程度上保持在整个成年期.
研究的目的:
- 为了研究成年人一生中大脑不对称度的纵向变化.
- 探索大脑不对称性变化与现象,生活方式和健康变量之间的联系.
主要方法:
- 利用英国生物库,一个大规模的纵向脑成像资源.
- 分析了整个大脑的不对称模式及其与11个类别的959个变量之间的关联.
- 与生活方式标记,生活过渡 (例如退休) 和约4500个医学诊断相关的不对称性变化.
主要成果:
- 在整个成年期中,大脑不对称性的持续变化得到证明,这表明神经可塑性正在持续.
- 确定了强大的全现象关联与各种变量间的不对称性变化.
- 发现大脑不对称的变化与生活方式的变化,退休过渡同时发生,并且与主要疾病类别相关.
结论:
- 大脑不对称性在整个成年期都是动态的和适应性的,这与神经系统的保存观念相反.
- 这些不断变化的大脑模式与个人经验,生命阶段和健康结果有关.
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