银河糖缺乏IgA1与转林受体1的溶解体介导的聚合与IgA脏病相关

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Meijun Si1,2, Jingpeng Fu3,4, Mengting Fang1,2

  • 1Department of Nephrology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.

Nature communications
|July 2, 2025
PubMed
概括

在IgA脏病 (IgAN) 中,缺乏银糖的IgA1 (Gd-IgA1) 保留是由转移素受体1 (TfR1) 与介质细胞溶解体结合的介导. 这一过程导致聚合物形成,溶酶体功能障碍和炎症,提供了潜在的治疗点.

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