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Updated: Sep 17, 2025

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine
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甲基酸盐受体4介导的谷氨酸基信号通过调节树突细胞成熟来重塑瘤微环境

Xiaoman Ju1, Eva Maria Putz2, Yaqi Liu1

  • 1Department of Pathogen Biology and Immunology, Jiangsu Key Laboratory of Immunity and Metabolism, Jiangsu International Laboratory of Immunity and Metabolism, Xuzhou Medical University, Xuzhou, Jiangsu, China.

Nature communications
|July 2, 2025
PubMed
概括

甲基增生谷氨酸受体4 (mGluR4) 缺乏会增强树突细胞功能,增强抗瘤免疫力. 这种非神经元机制在临床前模型中抑制瘤生长和转移,突出显示mGluR4作为免疫治疗点.

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