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Updated: Sep 17, 2025

Measuring Composition of CD95 Death-Inducing Signaling Complex and Processing of Procaspase-8 in this Complex
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在固体癌症免疫治疗中通过等离子体对人类Fas联体 (CD95L) 的进化调节

Brice E N Wamba1,2, Tanmoy Mondal1,2, Francis Freenor V1,2

  • 1Laboratory of Novel Biologics, University of California Davis, Davis, CA, USA.

Nature communications
|July 2, 2025
PubMed
概括

人类的癌症发病率比灵长类更高,原因是Fas Ligand (FasL) 蛋白质的变化. 这种变化使人体FasL易受瘤中的等离子素的影响,阻碍T细胞杀死癌症. 抑制等离子素可能会改善癌症免疫疗法.

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