相关实验视频

Updated: Sep 17, 2025

Monitoring GPCR-β-arrestin1/2 Interactions in Real Time Living Systems to Accelerate Drug Discovery
08:21

Monitoring GPCR-β-arrestin1/2 Interactions in Real Time Living Systems to Accelerate Drug Discovery

Published on: June 28, 2019

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螺旋束和C端GPCR域对GRK特异性功能和β-阿雷斯介导调节有不同的影响

Edda S F Matthees1, Raphael S Haider1,2,3, Laura Klement1

  • 1Institut für Molekulare Zellbiologie, CMB - Center for Molecular Biomedicine, Universitätsklinikum Jena, Friedrich-Schiller-Universität Jena, Jena, Germany.

Nature communications
|July 2, 2025
PubMed
概括

这项研究揭示了G蛋白结合受体 (GPCR) 的特定域如何控制β-arrestin (β-arrestin) 相互作用和信号传递. 了解这些GPCR-arrestin动态,可以澄清受体特定的信号机制.

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Parallel Interrogation of β-Arrestin2 Recruitment for Ligand Screening on a GPCR-Wide Scale using PRESTO-Tango Assay

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A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators07:41

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators

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Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
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Sensory...
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