向前带带皮层的副腹腔下丘脑输入控制了慢性内脏疼痛小鼠的食物偏好
Qi-Ya Xu1,2, Ying Kong3, Xiao-Wen Meng1,2
1Department of Anesthesiology, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.
Nature communications
|July 2, 2025
概括
慢性内脏疼痛通过改变神经回路来改变食物偏好. 从副腹腔下丘脑到前带皮质的特定通路调节了这些味觉变化,提供了潜在的治疗点.
科学领域:
- 神经科学是一个神经科学.
- 疼痛研究 疼痛研究
- 行为科学 行为科学
背景情况:
- 慢性内脏疼痛往往导致改变食物偏好.
- 副腹腔下丘脑 (PVH) 和前环皮质 (ACC) 参与疼痛和养行为.
- 连接这些区域的神经回路在疼痛引起的食欲变化中并未得到充分理解.
研究的目的:
- 研究从PVH到ACC的胆囊托基宁 (CCK) 神经元通路在慢性内脏疼痛期间调节食物偏好的作用.
主要方法:
- 使用了由新生儿结肠炎症 (NCI) 引起的慢性内脏疼痛的小鼠模型.
- 使用化学遗传学来操纵PVHCCK到ACCGlu电路.
- 评估了食物偏好的变化 (糖与脂肪) 和疼痛行为.
- 在ACC中使用CCK受体激动剂/对抗剂,以确认途径的参与.
主要成果:
- 患有NCI的小鼠更喜欢糖糖而不是内脂蛋白.
- 抑制PVHCCK到ACCGlu电路可以减少疼痛,并将偏好转移到内脂.
- 激活这个电路会增加疼痛,并将偏好转移到糖糖.
- 针对ACC中的CCK受体的药理干预可以逆转这些行为变化.
结论:
- PVHCCK到ACCGlu电路是编码慢性内脏疼痛中改变食物偏好的关键神经基质.
- 针对这种电路代表了管理与疼痛相关的食欲变化的潜在治疗策略.
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