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Updated: Sep 17, 2025

Functional Characterization of RING-Type E3 Ubiquitin Ligases In Vitro and In Planta
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对人类HRD1无素结合酶复合体的结构洞察

Liling Guo1,2, Guoyun Liu2, Jingjing He2

  • 1Department of General Medicine, The First Affiliated Hospital of USTC, MOE Key Laboratory for Membraneless Organelles and Cellular Dynamics, Hefei National Research Center for Interdisciplinary Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.

Nature communications
|July 2, 2025
PubMed
概括

HRD1 泛基因酶复合体对内分泌网膜相关蛋白质降解 (ERAD) 至关重要,在与德林蛋白相互作用时经历了显著的结构变化,揭示了其分子机制.

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