心血管疾病患者的虚弱状态和认知功能之间的关联:全国范围的队列研究
Wanchunxue Jiang1,2, Meng Wei1,2, Qianhui Wang1,2
1Department of Cardiac Pacing and Electrophysiology, the First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830000, Xinjiang, China.
Scientific reports
|July 2, 2025
概括
心血管疾病患者的虚弱和认知功能显示出一种动态的相互作用. 早期的虚弱可能会影响认知,而晚期的虚弱会随着时间的推移显著损害认知功能.
科学领域:
- 老年学是一门学科.
- 心脏病学 心脏病学
- 神经科学是一个神经科学.
背景情况:
- 心血管疾病 (CVD) 经常与虚弱和认知障碍同时发生.
- 心血管疾病患者的虚弱和认知功能之间的复杂关系和时间动态尚不清楚.
研究的目的:
- 研究心血管疾病的中国成年人的虚弱和认知功能之间的纵向关联和双向相互作用.
- 通过使用先进的统计模型来探索潜在的因果关系.
主要方法:
- 采用了一个队列研究设计,专注于中年和年长的中国成年人心血管疾病.
- 交叉滞后的面板模型分析被用来评估多个时间点的脆弱性和认知功能之间的时间相互作用.
主要成果:
- 认知功能表现出显著的自回归稳定性,预测未来的认知表现.
- 早期的脆弱性积极预测认知功能,但这种关联在后期阶段显著转变为负面影响.
- 对于脆弱性和认知功能,观察到双向关联和时间稳定性.
结论:
- 虚弱和认知功能在患有心血管疾病的个体中具有动态和双向联系.
- 虚弱对认知功能的影响随着时间的推移而演变,在以后的阶段变得有害.
- 了解这些时间相互作用对于管理心血管疾病患者的并发症至关重要.
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