移植前透析持续时间对延迟移植功能和接受者死亡之间的关系的影响
Rui-Yu Wang1, Dan Jia1, Shuan-Hong Wang2
1Urology Center, The First Hospital of Jilin University, No.71, Xinmin Street, Changchun, 130021, Jilin, China.
Scientific reports
|July 2, 2025
概括
延迟移植功能 (DGF) 在已故捐赠者移植后增加接受者死亡风险,特别是在接受更长时间的移植前透析的患者中. 透析的持续时间改变了DGF.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 移植免疫学 移植免疫学
- 临床研究临床研究
背景情况:
- 延迟移植功能 (DGF) 是移植后的一个已知的并发症.
- 需要进一步研究DGF对接受者长期存活的影响,特别是与移植前透析持续时间有关的影响.
研究的目的:
- 评估DGF在已故捐赠者移植后接受者死亡的影响.
- 根据移植前透析持续时间来分层这一效应.
- 在特定的患者子组中开发接受者死亡的预测模型.
主要方法:
- 来自1311名接受已故捐赠者移植的患者的临床数据的回顾性分析.
- 单变量和多变量考克斯回归分析以评估DGF和接受者死亡.
- 竞争风险分析和子组分析,以探索相互作用和风险因素.
主要成果:
- 独立地,DGF与接受者的死亡风险增加有关 (HR:2.672).
- 观察到DGF和移植前透析持续时间与接受者死亡之间的显著相互作用 (P=0.037).
- 在长期透析 (>24.7个月) 的患者中,DGF,接受者年龄和供体年龄是死亡的独立风险因素.
结论:
- 移植前透析的持续时间是决定DGF是否影响接受者生存的关键因素.
- 仅在移植前扩展透析的患者中,DGF是移植后3年内接受者死亡的独立风险因素.
- 结合DGF,接受者年龄和捐赠者年龄的预测模型对长期透析患者表现出很好的准确性.
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