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估计的脉冲波速度与急性缺血性中风患者的死亡风险之间的关联

Yaxin Zhang¹, Pingping Cai¹, Yadong Wu¹

¹Department of Neurology, Xiamen Humanity Hospital, Fujian Medical University, No. 3777 XianYue Road, Xiamen, 361009, Fujian, China.

Scientific reports

|July 2, 2025

概括

估计的脉冲波速度 (ePWV) 预测了急性缺血性中风 (AIS) 患者的死亡率. 较高的ePWV与死亡风险增加有关,有助于识别高风险个体.

科学领域:

心血管医学心血管医学
神经学神经学
生物医学工程生物医学工程

背景情况:

估计的脉冲波速度 (ePWV) 是急性缺血性中风 (AIS) 死亡率的预测指标.
通过ePWV表示的动脉硬性,越来越被认为是心血管健康的重要因素.

研究的目的:

评估EPWV与AIS患者全因死亡率之间的关联.
确定ePWV是否可以作为AIS患者死亡风险分层的预后工具.

主要方法:

对2176名AIS患者的分析,使用年龄和平均血压计算ePWV.
分为高和低 ePWV 组的分层,使用考克斯的比例危险模型和受限立方线分析.
使用ROC曲线下的面积 (AUC) 和子组分析评估预测性表现.

主要成果:

较高的ePWV独立地与30,90,180和360天的死亡率增加有关 (调整后的HRs在1.54至1.60之间,P<0.001).
卡普兰-梅尔分析显示,高EPWV组的生存率明显较低 (P < 0.001).
将ePWV与SOFA得分相结合,改善了预后准确性 (AUC高达0.72),表现优于年龄+SOFA.

结论:

升高的ePWV是AIS患者死亡率增加的独立预测因素.
ePWV是一种简单的,非侵入性的动脉硬度指标,对风险分层有价值.
ePWV有助于早期识别高风险的AIS患者,以加强管理.

关键词:

急性缺血性中风是一次急性缺血性中风.所有原因的死亡率.估计的脉冲波速度估计的脉冲波速度.这是一个MIMIC-IV数据库.风险分层是指风险的分层.

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