主观痛苦调解了COVID 19后患者的嗅觉功能障碍持续时间和抑郁症之间的关联
Jae Hyun Yoo1, Tae-Suk Kim1, Ji Sun Kim2
1Department of Psychiatry, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Scientific reports
|July 2, 2025
概括
在COVID-19之后的嗅觉功能障碍可能会使抑郁症状恶化. 嗅觉丧失的主观痛苦,而不仅仅是持续时间,似乎是关键因素,这表明在康复的患者中需要心理健康支持.
科学领域:
- 神经学 神经学
- 精神病学是一个精神病学.
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 嗅觉功能障碍 (OD) 是一个已知的COVID-19后症状.
- 与其他原因引起的OD患者相比,COVID-19相关的OD患者报告了更严重的精神症状.
- 了解COVID-19引起的OD的心理影响至关重要.
研究的目的:
- 为了比较COVID-19后OD患者与其他病因OD患者之间的心理症状和临床因素.
- 为了研究嗅觉功能,OD持续时间和心理痛苦之间的关系.
- 在COVID-19幸存者中确定OD持续时间和抑郁症状之间的关联中的潜在调解者.
主要方法:
- 招募了52名参与者 (26名COVID-19组,26名非COVID-19组).
- 评估客观和主观的嗅觉功能.
- 测量抑郁症 (PHQ-9),焦虑,感知压力和嗅觉障碍负面陈述 (sQOD-NS) 使用经过验证的尺度.
主要成果:
- 两组之间客观/主观嗅觉功能或一般心理症状没有显著差异,除了年龄和sQOD-NS.
- 仅在COVID-19组中,sQOD-NS得分与OD持续时间有负相关性.
- 在这两组中,sQOD-NS与PHQ-9分数有显著的相关性.
- 调解分析显示,OD持续时间通过sQOD-NS间接影响抑郁症状 (PHQ-9),特别是在COVID-19组.
结论:
- 与嗅觉功能障碍相关的主观痛苦可能会调解COVID-19幸存者的OD持续时间和抑郁症之间的联系.
- 这些发现强调了解决COVID-19相关OD的心理后果的重要性.
- 在COVID-19康复后经历嗅觉功能障碍的个体,建议针对性精神干预.
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