激进的血清性卵巢癌亚型是由高中心性 lncRNA 配置文件和主转录因子定义的
Seonhyang Jeong1,2, Young Suk Jo1, Sunmi Park1
1Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.
Scientific reports
|July 2, 2025
概括
这项研究使用长非编码RNA (lncRNAs) 来分类高度血清性癌卵巢癌 (HGSC),揭示了五种不同的分子亚型. 这些lncRNAs和主转录因子 (MTFs) 提供了个性化医学的潜力.
科学领域:
- 基因组学就是基因组学.
- 分子生物学分子生物学
- 在瘤学瘤学.
背景情况:
- 长非编码RNAs (lncRNAs) 在高度血清性癌卵巢癌 (HGSC) 的进展和转移中至关重要.
- 目前的HGSC分类缺乏基于转录的分层, lncRNAs与主转录因子 (MTFs) 之间的相互作用不太清楚.
研究的目的:
- 根据lncRNA表达特征对HGSC进行分类.
- 识别HGSC亚型中与lncRNAs和mRNAs共同调节的集成MTF.
- 研究lncRNAs和MTFs在HGSC病原发生中的功能性作用.
主要方法:
- 来自367个HGSC样本的ncRNA表达数据的无监督聚类 (癌症基因组图谱).
- 对遗传 (DNA突变,拷贝数变化) 和表观遗传 (microRNA表达,DNA甲基组) 因素的分析.
- 通过丰富的Regulon (msViper) 应用多样样蛋白活性虚拟推断来识别相关的转录因子.
- 在体外实验验证 lncRNA-MTF-mRNA调节关系.
主要成果:
- HGSC被分为五种不同的分子亚型:"免疫"",EMT"",雌激素反应"",EMT-雄激素反应"和"差异化".
- "EMT-雄激素反应"组表现出较差的瘤学结果.
- 在预后不佳组中,七个lncRNA的网络中心性高于前三个识别的MTF (MSC,AEBP1,CREB3L1).
结论:
- lncRNA表达为将HGSC分类为临床相关的分子亚型提供了坚实的基础.
- lncRNA和MTF在塑造HGSC分子特征方面表现出协同作用.
- 这些发现突出了lncRNAs和MTFs作为个性化HGSC医学的潜在生物标志物和治疗点.
相关概念视频
lncRNA - Long Non-coding RNAs
9.0K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.0K
mTOR Signaling and Cancer Progression
3.9K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.9K
Tumor Progression
6.5K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.5K
Cancers Originate from Somatic Mutations in a Single Cell
13.0K
Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
13.0K
Master Transcription Regulators
7.1K
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
7.1K
Adaptive Mechanisms in Cancer Cells
5.9K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
5.9K


