久坐不动的行为加速了成年人通过体重指数调解的生物衰老
Jinhang Che1, Jie Huai1, Lihong Luo1
1Department of Electrocardiographic Diagnosis, The Fourth People's Hospital of Chengdu, Chengdu, China.
Scientific reports
|July 2, 2025
概括
长时间的坐着时间显著增加了加速衰老的风险,通过表型年龄加速 (PhenoAgeAccel) 来衡量. 身体质量指数 (BMI) 部分调解了这种关系,突出了久坐行为对健康的影响.
科学领域:
- 老年学是一门学科.
- 公共卫生 公共卫生
- 生物统计学 生物统计学
背景情况:
- 久坐不动的行为,特别是长时间的坐着,是众所周知的健康风险.
- 坐着时间和生物标志物测量的衰老之间的关联仍然不够理解.
- 现型年龄加速 (PhenoAgeAccel) 为评估生物衰老提供了一个新的指标.
研究的目的:
- 在大量成年人群中调查坐着时间和PhenoAgeAccel之间的关系.
- 为了检查静坐时间和生物衰老之间的剂量反应关系.
- 探索身体质量指数 (BMI) 在这个协会中的调解作用.
主要方法:
- 来自2007-2016年国家健康和营养检查调查 (NHANES) 的12504名成年人的分析.
- 权重后勤回归和受限立方线回归来评估坐时间和PhenoAgeAccel.
- 调解分析以评估BMI的作用.
主要成果:
- 增加的坐时间 (≥4小时/天) 与更高的PhenoAgeAccel风险显著相关.
- 在坐着时间和衰老风险之间观察到剂量-反应,大约是线性关系.
- 体重指数部分调解了坐着时间和PhenoAgeAccel之间的关系的21.0%.
结论:
- 长时间的坐着时间和加速的表型衰老之间存在显著的,独立的和线性关系.
- 体重指数 (BMI) 在静坐行为与生物衰老之间的联系中起着部分调解作用.
- 减少坐着的时间可能是缓解与年龄相关的健康衰退的关键策略.
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