系统性炎症在正常的BMI成年人中部分调解了脂质积累和骨关节炎之间的关联
Dapeng Zhang1, Jie Mei2, Qiang He3
1Nanjing University of Chinese Medicine Affiliated Nanjing Hospital of Traditional Chinese Medicine, Nanjing, China.
Scientific reports
|July 2, 2025
概括
高脂积累产物 (LAP) 水平与骨关节炎 (OA) 风险增加有关,即使在正常的BMI个体中也是如此. 通过SIRI表示的全身炎症部分介导了这一关联,特别是在年轻女性中.
科学领域:
- 生物医学研究生物医学研究
- 流行病学 流行病学
- 代谢健康 代谢健康
背景情况:
- 骨关节炎 (OA) 是一种普遍存在的退行性关节疾病.
- 肥胖是关节炎的已知危险因素,但正常体重个体的相关性需要进一步调查.
- 脂质积累产物 (LAP) 和全身炎症反应指数 (SIRI) 是代谢功能障碍的新兴生物标志物.
研究的目的:
- 调查LAP水平与正常体重指数 (BMI) 的成年人中OA患病率之间的关联.
- 探索SIRI在LAP和OA之间的关系中扮演的调解角色.
- 确定特定的人口亚组,如年轻女性,他们可能更容易受到这些关联的影响.
主要方法:
- 从国家健康和营养检查调查 (NHANES) 数据库 (2009-2018) 的数据分析.
- 包括正常BMI的参与者.
- 权重多变量后勤回归和调解分析,以评估LAP,SIRI和OA流行之间的关联.
主要成果:
- 在正常的BMI参与者中,LAP水平的最高四分位数与较高的OA患病率 (AOR=1.969) 和较高的SIRI水平 (AOR=1.174) 有显著的关联.
- 较高的SIRI水平也与较高的骨关节炎患病率 (AOR=1.542),特别是年轻女性显著相关.
- SIRI部分调解了LAP和OA之间的关联 (10.30%调解),在年轻人 (8.92%) 和女性 (8.69%) 中显著调解.
结论:
- 高水平的LAP独立地与增加的骨关节炎患病率有关,即使在正常BMI的个体中也是如此.
- 根据SIRI的指标,系统性炎症在这种关联中发挥了部分调解作用.
- 年轻女性代表了一个人口群体,LAP,SIRI和OA患病率之间的相互作用特别明显.
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