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断奶期间HD5对Bifidobacterium的调制与晚年生活中的高丰度有关

Yu Shimizu^1,2,3, Yuki Yokoi^1,4, Shuya Ohira^1,5

¹Innate Immunity Laboratory, Faculty of Advanced Life Science, Hokkaido University, Hokkaido, Japan.

Communications medicine

|July 2, 2025

概括

早期生活Bifidobacterium殖民,受人类防御素5 (HD5) 的影响,对于在儿童中建立健康的肠道微生物群至关重要. 这种早期的殖民影响到三岁时的肠道微生物组合.

科学领域:

微生物学微生物学
免疫学免疫学免疫学
人类健康人类健康人类健康

背景情况:

双杆菌的殖民化为整个生命带来了健康益处.
新生儿Bifidobacterium殖民的机制及其对肠道微生物群的长期影响仍然不清楚.
α-Defensin (例如,人体防御素5 - HD5) 选择性地向病原体,节省像Bifidobacterium这样的共生菌,从而调节肠道微生物群.

研究的目的:

在生命早期调查HD5和Bifidobacterium殖民之间的关系.
确定早期的Bifidobacterium殖民是否会影响生命后期建立一个富含Bifidobacterium的微生物群.

主要方法:

在日本对33对母婴对进行的纵向队列研究 (SMILE Iwamizawa).
从出生后的3-5天到3岁,连续采集便样本.
评估微生物群组成和HD5水平.

主要成果:

HD5与Bifidobacterium在生命早期的殖民形成有积极的相关性,特别是在断奶前和断奶期间.
断奶期间高Bifidobacterium丰富度,与HD5分泌相关,预测3年后一个富含Bifidobacterium的微生物群.
这表明HD5在Bifidobacterium肠道早期殖民中起作用.

结论:

断奶期对于建立持久的肠道平衡至关重要.
主体天生的免疫力,特别是HD5,和Bifidobacterium相互作用,塑造正在发展的肠道微生物群.
早期的肠道微生物组发育受到宿主微生物相互作用和天生的免疫力的影响.

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