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极性蛋白Par6通过与aPKC的动态相互作用促进Lgl的过程性酸化

Lior Almagor1,2, William I Weis3,4

  • 1Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA. lalmagor@stanford.edu.

Communications biology
|July 2, 2025
PubMed
概括

表皮细胞的极性取决于非典型的蛋白质激酶-C (aPKC) /Par6复合物化Lethal巨型幼虫 (Lgl) 蛋白质. 这项研究表明,Par6稳定了该复合体,使Lgl高效酸化和调节膜结合成为可能.

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