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Updated: Sep 17, 2025

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酸优先杀死KRAS突变胰腺癌细胞通过DNA损伤

Hye-Lim Jang1,2, Seung Tae Kim1, Jung Yong Hong1

  • 1Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro Gangnam-gu, Seoul, 06351, Korea.

Scientific reports
|July 2, 2025
PubMed
概括

高剂量的L-亚斯科布酸 (AA) 通过破坏糖解并导致DNA损伤,有效地抑制胰腺癌 (PC) 的生长,特别是在KRAS G12D突变细胞中. 这表明AA作为特定PC患者子集的潜在新疗法.

关键词:
造成的DNA损伤是DNA损伤.克拉斯 (Kras) 是一个国家.L-阿斯科布酸是一种L-阿斯科布酸.胰腺癌是一种胰腺癌.

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