在中脑动脉动脉瘤中,在生长阶段,血液动力学评估破裂风险,这些动脉瘤接受了卷曲治疗
Rifaqat Ali1, Hana Ihsan Hassan2, Aman Sharma3
1Department of Mathematics, Applied College in Mohayil Asir, King Khalid University, Abha, Saudi Arabia. rrafat@kku.edu.sa.
Scientific reports
|July 2, 2025
概括
动脉瘤的生长通过破坏血液流动的稳定性增加了破裂的风险. 血管内线圈有效地减少了血液动力学压力和流动复杂性,稳定了中脑动脉动脉瘤,无论大小如何.
科学领域:
- 生物医学工程 生物医学工程
- 流体动力学 流体动力学
- 神经外科 神经外科
背景情况:
- 内动脉瘤破裂是一个关键的问题,特别是中脑动脉 (MCA) 动脉瘤.
- 动脉瘤囊体积增长与血液动力学不稳定性和破裂风险增加有关.
研究的目的:
- 为了研究动脉瘤囊扩大对血液动力学参数的影响.
- 评估内血管卷膜在稳定不同大小的动脉瘤中的生物力学有效性.
主要方法:
- 使用患者特定的计算流体动力学 (CFD) 模拟.
- 模拟包括基线和缩放动脉瘤几何形状 (16mm3,24mm3,32mm3) 在脉动性流动下.
- 使用非牛顿式的血液风湿学 (卡森模型) 和绕作为多孔介质 (多孔度0.65).
主要成果:
- 动脉瘤的生长显著提高了血液动力学压力标志物,如峰值壁切削应力 (WSS),平均WSS和振荡式切削指数 (OSI).
- 在没有处理的情况下,OSI达到0.28左右,WSS超过120Pa,表明高流动不稳定.
- 在所有模拟体积中,内血管线圈始终降低了峰值WSS (<100Pa),平均WSS (<5Pa) 和OSI (<0.03).
结论:
- 动脉瘤囊的生长加剧了与破裂风险相关的血液动力学条件.
- 血管内线圈通过减少生物力学压力和流动复杂性,有效地稳定动脉瘤.
- 线圈在缓解生长动脉瘤中不利的血液动力学变化方面表现出一致的有效性.
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