咖啡因摄入与骨质疏松症风险相反相关,基于横截面和遗传证据
1Guangzhou University of Chinese Medicine, Guangzhou, 510405, China. lqp67887@163.com.
Scientific reports
|July 2, 2025
概括
更高的咖啡因摄入量与明显降低骨质疏松症 (OP) 风险有关. 这项研究发现,与低咖啡因消费者相比,消费咖啡因最多的人患OP的风险降低了60%.
科学领域:
- 营养科学 营养科学
- 骨健康研究 骨健康研究
- 流行病学 流行病学
背景情况:
- 骨质疏松症 (OP) 是一个重要的公共卫生问题,其特点是骨质量低和微型结构恶化.
- 饮食因素,包括咖啡因消耗,正在越来越多地研究它们在骨代谢和OP风险中的潜在作用.
研究的目的:
- 调查咖啡因摄入量与骨质疏松症之间的关联.
- 通过使用遗传数据来确定咖啡因摄入是否对骨质疏松症风险具有因果关系.
主要方法:
- 使用后勤回归,限制立方线 (RCS) 和子组分析,对国家健康和营养检查调查 (NHANES) 数据 (2017-2020) 的横截面分析.
- 门德尔随机化 (MR) 分析采用逆方差加权 (IVW) 方法来评估因果关系.
主要成果:
- 后勤回归显示,最高的咖啡因摄入量 (>166.5毫克/天) 与60%较低的OP风险相关 (OR=0.401,P=0.049).
- RCS分析显示了一个L形曲线,表明随着咖啡因摄入量增加,OP风险的下降趋势 (P-非线性=0.013).
- 核磁共振分析证实了咖啡摄入量与OP (OR=0.982,P<0.001) 之间的负因果关系.
结论:
- 这项研究提供了强有力的证据,结合了观察和遗传数据,证明咖啡因摄入对骨质疏松症的保护作用.
- 种族,吸烟,和年龄等因素显著改变了咖啡因和OP风险之间的关系.
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