人体肠道细菌生物积累的每和多基基物质
Anna E Lindell1, Anne Grießhammer2, Lena Michaelis2
1Medical Research Council Toxicology Unit, University of Cambridge, Cambridge, UK.
Nature microbiology
|July 2, 2025
概括
人体肠道细菌可以积累高水平的持久污染物,如和多醇基物质 (PFAS). 这项研究揭示了PFAS在各种肠道微生物中的显著生物积累,影响其环境和健康.
科学领域:
- 环境科学 环境科学
- 微生物学 微生物学
- 毒理学 毒理学 毒理学
背景情况:
- 和多基基物质 (PFAS) 是具有重大健康问题的持续性环境污染物.
- 尽管PFAS在人类微生物群中普遍存在,但PFAS与人类肠道细菌的相互作用仍然基本上是未知的.
研究的目的:
- 为了研究人类肠道细菌对PFAS的生物积累能力.
- 了解PFAS与肠道微生物群相互作用的机制和影响.
主要方法:
- 对38种肠道细菌菌株进行PFAS生物积累的查.
- 使用低温聚焦离子束二次离子质谱法 (cryo-FIB-SEM) 进行细胞内定位.
- 采用蛋白质组,代谢组和小鼠殖民模式来评估PFAS的影响和运输.
主要成果:
- 在38种肠道细菌菌株中显示出显著的PFAS生物积累,其中一些达到毫米级细胞内度.
- 在大肠杆菌中确定了活跃的跨膜传输机制,由于没有TolC排泄,这种机制得到了增强.
- 在大肠杆菌中确认了细胞内PFNA的局部化,并且在人类肠道细菌殖民的小鼠便中观察到更高的PFNA水平.
结论:
- 肠道细菌具有相当大的 PFAS 生物积累能力,挑战了以前的假设.
- 这些发现突出了肠道微生物群在PFAS在人体和环境中的命运和运输中的潜在作用.
更多相关视频
09:04Identifying Per- and Polyfluorinated Chemical Species with a Combined Targeted and Non-Targeted-Screening High-Resolution Mass Spectrometry Workflow
Published on: April 18, 2019
12.6K
13:16A Whole Cell Bioreporter Approach to Assess Transport and Bioavailability of Organic Contaminants in Water Unsaturated Systems
Published on: December 24, 2014
10.5K
相关概念视频
Biofilms
297
Biofilms are complex communities of microorganisms encased in a self-produced extracellular polysaccharide matrix attached to surfaces. These microbial consortia can include single or multiple species, providing enhanced survival benefits by forming organized, multilayered structures.The formation of biofilms occurs through four key stages: attachment, colonization, development, and dispersal.During attachment, free-swimming planktonic cells adhere to a surface, often facilitated by...
297
Types of Toxins
2.0K
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
2.0K
Bacterial Flora of the Large Intestine
653
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
653
