创伤后应激障碍的共同遗传结构与心血管成像,风险和诊断
Jie Shen1,2, Wander Valentim2,3, Eleni Friligkou2,4
1Department of Cardiology, Children's Hospital of Soochow University, Suzhou, China.
Nature communications
|July 2, 2025
概括
这项研究揭示了创伤后应激障碍 (PTSD) 和心血管疾病之间的共同遗传联系. 识别这些遗传关联可以为PTSD患者的心血管疾病的未来预防和治疗策略提供信息.
科学领域:
- 遗传学 是一个遗传学.
- 心血管医学 心血管医学
- 精神病学是一个精神病学.
背景情况:
- 患有创伤后应激障碍 (PTSD) 的患者患心血管疾病的风险更高.
- 了解PTSD和心血管疾病之间的共同生物学基础对于开发有针对性的干预措施至关重要.
研究的目的:
- 研究创伤后应激障碍和广泛的心血管疾病之间的共同遗传区域和因果变异.
- 通过使用遗传和观察数据,探索PTSD和心血管诊断,成像特征和健康行为之间的关联.
- 识别与PTSD和心血管疾病相关的共享基因和生物途径.
主要方法:
- 进行了全基因组关联研究 (GWAS),以确定PTSD和246种心血管疾病之间共享的遗传位置.
- 分析包括电子健康记录,心脏成像数据和健康行为 (Life's Essential 8).
- 在AllofUS队列中进行了观测分析,并在大脑和血液组织中进行了基因调节的蛋白质体表达.
主要成果:
- 33个遗传区域,4个成像特征和44个健康行为区域显示了与PTSD的遗传相关性.
- 对于17种心血管疾病,在11个地区确定了潜在的共同因果变异.
- 在AllofUS队列中,PTSD与13种心血管诊断有关,独立于社会经济因素和抑郁症.
- 33个血液和122个大脑基因被确定为共享的,涉及神经元,免疫,代谢和与相关的途径.
结论:
- 共享的遗传风险位置和基因有助于在PTSD患者中观察到的心血管风险增加.
- 已识别的基因和途径为患有PTSD的个体管理心血管疾病提供了潜在的治疗点.
- 这些发现突出了导致PTSD和心血管疾病共患的组织特异性生物机制.
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