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遗传风险通过大脑功能和生理衰老的性差异化预测了青少年情绪病理

Raluca Petrican¹, Alex Fornito², Christopher Murgatroyd³

¹Institute of Population Health, Department of Psychology, University of Liverpool, Bedford Street South, Liverpool, L69 7ZA, UK. raluca.petrican@liverpool.ac.uk.

Nature communications

|July 2, 2025

概括

青少年的大脑显示区域性差异,而不仅仅是整体差异. 大脑的女性化与早期的青春期和健康问题有关,而男性化与晚期的青春期和更好的健康有关,影响情绪障碍.

科学领域:

神经科学是一个神经科学.
发展心理学发展心理学
精神病学是一个精神病学.

背景情况:

传统的性别差异研究将大脑整体分类,忽视了个体差异.
青春期是大脑发育的关键时期,是性别特异性对精神疾病的脆弱性出现的关键时期.
了解区域大脑的性差异化对于个性化精神病学干预至关重要.

研究的目的:

调查假设,区域性脑功能差异化,而不是分类性的性别方法,是理解青少年精神疾病的关键.
检查大脑性差异化,青春期,免疫/代谢调节和青少年情绪/行为症状之间的关系.

主要方法:

在男性和女性青少年的纵向 (N=199) 和横截面 (N=277) 研究中.
评估大脑网络中的区域性差异化 (关联与感官).
与青春期时间,免疫/代谢失调,遗传风险和情绪/行为症状的相关性分析.

主要成果:

协会网络在9-10岁时更大的女性化与更早的青春期相关,并在11-12岁时增加免疫/代谢失调,特别是在女孩身上.
协会网络的更大男性化与晚年青春期和免疫/代谢调节障碍的减少相关,特别是在男孩中.
大脑和生理特征顺序介绍了遗传风险和情绪/行为症状之间的联系,跨性别都是如此.

结论:

区域大脑的性差异化,而不仅仅是整体的性别分类,对于理解青少年发育和精神病的脆弱性很重要.
大脑性差异化,青春期发育和生理调节之间的相互作用影响情绪和行为结果.
整合区域大脑性差异化和生理学的评估对于青少年个性化精神干预至关重要.

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