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Updated: Sep 17, 2025

Visualization of Mitochondrial Respiratory Function using Cytochrome C Oxidase / Succinate Dehydrogenase COX/SDH Double-labeling Histochemistry
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Visualization of Mitochondrial Respiratory Function using Cytochrome C Oxidase / Succinate Dehydrogenase COX/SDH Double-labeling Histochemistry

Published on: November 23, 2011

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自私的突变促进了哺乳动物mtDNA完整性的与年龄相关的侵蚀

Ekaterina Korotkevich1, Daniel N Conrad2, Zev J Gartner2

  • 1Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, USA. ekaterina.korotkevich@ucsf.edu.

Nature communications
|July 2, 2025
PubMed
概括

线粒体DNA (mtDNA) 突变随着年龄的增长而积累. 一种称为"驱动"的复制优势会放大这些突变,导致与年龄相关的疾病和线粒体疾病.

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