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Updated: Sep 17, 2025

Whisker-signaled Eyeblink Classical Conditioning in Head-fixed Mice
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奖励历史指导焦点注意力在胡须体感官皮质

Deepa L Ramamurthy1, Lucia Rodriguez1,2, Celine Cen1

  • 1Department of Neuroscience and Helen Wills Neuroscience Institute, UC Berkeley, Berkeley, CA, USA.

Nature communications
|July 2, 2025
PubMed
概括

根据奖励历史,小鼠可以灵活地在胡须之间转移触觉注意力. 这种注意力转移是由感官皮层调节的介导,增强对被照顾的胡须的反应.

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The somatosensory system relays sensory information from the skin, mucous membranes, limbs, and joints. Somatosensation is more familiarly known as the sense of touch. A typical somatosensory pathway includes three types of long neurons: primary, secondary, and tertiary. Primary neurons have cell bodies located near the spinal cord in groups of neurons called dorsal root ganglia. The sensory neurons of ganglia innervate designated areas of skin called dermatomes.
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Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
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The somatosensory system is the central and peripheral nervous system component that senses and processes touch, pressure, pain, temperature, and body position or proprioception. The process of sensation takes place at three levels:
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Olfaction

The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
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