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Updated: Sep 17, 2025

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors
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基因甲基化保护癌细胞免受衰老的影响

Xiaoying Chen1, Kosuke Yamaguchi2,3, Brianna Rodgers1

  • 1Université Paris Cité, CNRS, Epigenetics and Cell Fate, Paris, France.

Nature communications
|July 2, 2025
PubMed
概括

癌细胞中的DNA甲基化减少会诱导衰老,其特征是细胞循环停止和特定的分子标记. 这独立于DNA损伤发生,提供了新的治疗策略.

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