在COVID-19后的功能性大脑异常及其与认知关系
Lourdes Carreras-Vidal1,2, Laura Pacheco-Jaime1,2, Mar Ariza1,3
1Unitat de Psicologia Mèdica, Departament de Medicina, Institut de Neurociències, Universitat de Barcelona (UB), 08036, Barcelona, Catalunya, Spain.
Scientific reports
|July 2, 2025
概括
后COVID状态 (PCC) 患者显示大脑功能连接 (FC) 发生变化,这可能是一种低效的补偿机制. 这种大脑网络重组与认知问题和持续的PCC症状如疲劳相关.
科学领域:
- 神经科学是一个神经科学.
- 医疗成像医学成像
- 认知科学 认知科学
背景情况:
- 后COVID状态 (PCC),或长期COVID,经常涉及持续的认知功能障碍.
- 改变大脑功能连接 (FC) 是一个可疑的潜在机制,但其特定的网络特征和PCC中的临床相关性尚未得到充分理解.
研究的目的:
- 调查PCC患者与健康对照人群之间的网络内部和网络间功能连接 (FC) 差异.
- 检查PCC患者改变的FC,认知状态和临床结果之间的关系.
主要方法:
- 招募了121名PCC患者 (有/没有认知障碍) 和37名健康对照.
- 使用休息状态功能磁共振成像 (fMRI) 和全面的神经心理评估.
- 分析了静态网络,使用独立组件分析,双回归和网络建模来进行FC特征.
主要成果:
- 在10个认知网络中,PCC患者表现出增加的网络内部FC,包括默认模式和执行控制网络.
- 增加的FC与一般认知 (MoCA分数),感染后的时间,疲劳和主观记忆问题正相关.
- 在默认模式和传感器运动网络之间观察到高的网络间FC.
结论:
- 在PCC中增加的功能连接 (FC) 可能代表一个低效的补偿机制.
- 这些FC变化与关键的PCC症状有关,例如疲劳和主观记忆问题.
- 研究结果强调了大脑网络功能障碍与COVID后认知缺陷的持续存在之间的联系.
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