表达IL-15的介酶体 stromal 细胞的异质性控制了自然杀手细胞的发育和免疫细胞的稳态
Carmen Stecher1, Romana Bischl1, Anna Schmid-Böse1
1Center for Cancer Research, Medical University of Vienna and Comprehensive Cancer Center, Vienna, Austria.
Nature communications
|July 2, 2025
概括
骨髓中酶体 stromal 细胞 (MSC) 亚型差异性调节免疫细胞的发育. 特定的MSCs影响自然杀手 (NK) 细胞前体和T细胞存活率,突出了免疫细胞调节的功能异质性.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
- 血液形成 血液形成 血液形成
背景情况:
- 骨髓 (BM) 中酶体 stromal 细胞 (MSCs) 对于造血干细胞和造血至关重要.
- 在BMMSC亚型之间的功能异质性和它们在免疫细胞系发展中的作用尚未完全理解.
研究的目的:
- 研究不同的BM MSC亚型在调节IL-15依赖性免疫细胞系的发展和生存中的作用.
- 阐明MSC亚型对骨髓免疫细胞平衡的特定贡献.
主要方法:
- 使用了IL-15 knockin 记者小鼠模型.
- 采用多重条件删除小鼠模型来评估在特定结构细胞群 (Osx+,Lepr+) 中的IL-15表达.
- 分析了基因删除对自然杀手 (NK) 细胞前体,记忆CD8+ T细胞,NKT细胞和成熟NK细胞的影响.
主要成果:
- 在Osx+ stromal细胞中条件删除IL-15导致减少NK细胞前体,记忆CD8+T细胞和NKT细胞.
- 在老年小鼠中,Lepr+ stromal 细胞被发现支持成熟的 NK 细胞和记忆 CD8+ T 细胞的存活.
- 内皮细胞支持循环中的成熟NK细胞和记忆CD8+T细胞,但不在BM内.
结论:
- BM MSC亚型在调节免疫细胞发育和生存方面表现出不同的功能作用.
- 在特定的MSC亚型中IL-15表达对于某些免疫细胞系的发展至关重要.
- 在骨髓微环境中,MSC亚型差异性地支持成熟免疫细胞的生存.
相关概念视频
T Cell Types and Functions
1.4K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.4K
Regulation of Hematopoietic Stem Cells
3.3K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.3K
Multipotency of Hematopoietic Stem Cells
3.3K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
3.3K
Mesenchymal Stem Cells
5.0K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
5.0K
Lineage Commitment
3.1K
Commitment is the process whereby stem cells:
3.1K


