探索大麻醇悬浮液和口腔可分散膜的相互连接特性
Robert-Alexandru Vlad1, Andrada Pintea1, Paula Antonoaea2
1Pharmaceutical Technology and Cosmetology Department, Faculty of Pharmacy, "George Emil Palade", University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, 38 Gheorghe Marinescu Street, Târgu Mureș, 540142, Romania.
这项研究开发了使用大麻 (CBD) 治疗儿科的快速释放口腔可分散膜 (ODF). 一种配方,CBD-ODF2,显示出快速的API释放,证明了在儿童中有效的药物输送的潜力.
科学领域:
- 制药技术 制药技术 制药技术
- 药物输送系统 药物输送系统
- 儿科配方 儿科配方 儿科配方
背景情况:
- 伦诺斯-加斯托和德拉维特综合征是严重的儿科病.
- 大麻二醇 (CBD) 是一种具有治疗潜力的活性药物成分 (API).
- 儿科患者需要快速释放配方来提高遵守性和疗效.
研究的目的:
- 开发和描述含有大麻 (CBD) 的儿科用口腔可分散膜 (ODF).
- 为了确定合溶液分散/悬浮和最终的ODFs的特性之间的相关性.
- 评估含有CBD的ODF的制造工艺和药物释放特性.
主要方法:
- 空白环状分散物的表征 (扩散性,粘度,接触应力,pH).
- 评估空白和CBD装载的ODF (质量均,厚度,折叠耐久性,粉碎强度,分解,粘附).
- 使用皮尔森系数进行相关性分析;对悬浮物的颗粒大小评估.
主要成果:
- 在分散/悬浮特性和ODF参数之间发现了很少的统计学意义上的相关性.
- CBD-ODF2表现出快速的药物释放,近100%的API在30分钟内释放.
- CBD-ODF2的溶解行为与药典分解试验结果一致.
结论:
- 口腔可分散膜 (ODF) 显示出作为儿科CBD输送快速释放配方的承诺.
- 通过财产相关性了解制造过程对于ODF开发至关重要.
- CBD-ODF2表现出有利的溶解特性,这表明它适合用于儿科治疗.
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