在美国人口中,氧化应激和与代谢相关的脂肪肝疾病之间存在关联
Linyin Huang1, Shifang Qu1, Xinyu Cui2
1Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, No.1163 Xinmin Street, Changchun, 130021, Jilin, China.
Scientific reports
|July 2, 2025
概括
较高的氧化平衡得分 (OBS) 与代谢相关脂肪肝疾病 (MAFLD) 的风险较低有关. 抗氧化生活方式,而不仅仅是饮食,是预防MAFLD的关键.
科学领域:
- 代谢障碍 代谢障碍 代谢障碍
- 氧化压力研究研究 氧化压力研究
- 公共卫生 营养 公共卫生 营养
背景情况:
- 代谢相关脂肪肝疾病 (MAFLD) 的患病率正在上升,对氧化应激作用的研究有限.
- 氧化平衡评分 (OBS) 量化了个人的氧化应激状态,为人口健康评估提供了潜在的指标.
研究的目的:
- 在大量人群中调查氧化平衡评分 (OBS) 与代谢相关脂肪肝疾病 (MAFLD) 风险之间的关联.
- 探索潜在的机制,包括炎症标志物,胰岛素抵抗和BMI,调解OBS和MAFLD之间的关系.
- 评估OBS对MAFLD患者总死亡率的影响.
主要方法:
- 来自2003-2018年国家健康和营养检查调查 (NHANES) 的9881名参与者的分析.
- 采用了对共变量调整的回归模型,人口归因分数 (PAF) 分析,受限立方线 (RCS) 分析和中介分析.
- 研究了持续的OBS与MAFLD患者的总死亡率之间的关联.
主要成果:
- 在较高的OBS和降低的MAFLD风险之间发现了一个统计学上显著的反向关联 (Q4 vs Q1:OR = 0.60).
- 人口归因分数分析表明,较高的OBS可以解释显著的MAFLD减少 (12.67%为第四季度,8.00%为第三季度).
- 调解分析确定了胰岛素抵抗,炎症和BMI作为部分调解者. 持续的OBS与MAFLD患者的总死亡率降低有关 (HR = 0.97).
结论:
- 升高的OBS与美国人口中MAFLD患病率较低显著相关.
- 抗氧化剂的生活方式似乎比抗氧化剂饮食对预防MAFLD更为重要.
- 胰岛素抵抗,炎症和BMI在OBS-MAFLD关系中发挥作用,突出了潜在的治疗点.
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