对益生菌细菌Lactococcus lactis (MKL8) 的生物活性特性和代谢概况的全面评估
Tholla Madana Shivani1, Mythili Sathiavelu2
1School of Biosciences and Technology, Vellore Institute of Technology, Vellore, 632014, India.
Scientific reports
|July 2, 2025
概括
乳球菌乳糖MKL-8是一种来自Murraya koenigii的益生菌,显示出显著的抗氧化,抗糖尿病和抗炎作用. 这种多功能菌株还产生外聚糖和有益的代谢物,表明其在健康和食品应用方面的潜力.
科学领域:
- 微生物学 微生物学
- 益生菌 益生菌 益生菌
- 代谢学 代谢学 代谢学
背景情况:
- 益生菌研究寻求合成药物的天然替代品.
- 乳球菌乳酸菌MKL-8从Murraya koenigii中分离出来.
- 多功能益生菌提供多种健康益处.
研究的目的:
- 评估Lactococcus lactis MKL-8的生物活性和新陈代谢.
- 评估MKL-8作为多功能益生菌的适用性.
- 探索MKL-8在医疗保健和功能性食品中的潜力.
主要方法:
- 生物活性测定 (抗氧化剂,抗糖尿病,抗炎).
- 生物膜形成和外聚糖 (EPS) 合成分析.
- 使用气体染色学-质谱学 (GC-MS) 和里埃变换红外 (FT-IR) 谱学进行代谢分析.
主要成果:
- MKL-8表现出高的抗氧化 (90.19%),抗糖尿病 (60%的α-氨基酶抑制) 和抗炎症 (99%的蛋白质变性抑制) 活动.
- 该菌株表现出强烈的生物膜形成和显著的EPS合成.
- GC-MS和FT-IR确定了具有免疫调节,抗氧化,原蛋白合成和伤口愈合特性的代谢物.
结论:
- 乳球菌乳糖MKL-8是一种有前途的多功能益生菌,具有显著的生物活性特性.
- 已识别的代谢物支持MKL-8的潜在治疗应用.
- MKL-8是医疗保健和功能性食品行业的有价值候选者.
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