慢性乙型肝炎患者的病毒学反应和门静脉血栓症之间的相关性
Zhanghao Li1, Yingjun Jiang2, Shijin Wang1
1Gastroenterology Department, Affiliated Hospital of Qingdao University, Qingdao, 266100, Shandong, People's Republic of China.
Scientific reports
|July 2, 2025
概括
门静脉血栓塞 (PVT) 是慢性乙型肝炎 (CHB) 肝硬化患者的常见并发症. 对抗病毒疗法的有利病毒学反应可以显著降低这些患者PVT的风险.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 胃肠病学 胃肠病学
- 病毒学 病毒学
背景情况:
- 门静脉血栓症 (PVT) 是肝硬化的一个重要并发症,特别是在慢性乙型肝炎 (CHB) 患者中.
- 虽然乙型肝炎病毒 (HBV) 感染和血清学标记与PVT有关,但缺乏包含CHB肝硬化患者病毒学指标的预测模型.
研究的目的:
- 建立和验证PVT在CHB肝硬化患者中的临床预测模型.
- 确定风险因素并评估病毒学反应对这一群体PVT发展的影响.
主要方法:
- 对252名CHB患者进行了回顾性队列研究.
- 收集了基线数据,监测了PVT结果和抗病毒病毒学反应.
- 使用倾向性得分匹配 (PSM) 分析来控制混因素.
主要成果:
- 在随访期间,11.11%的患者出现PVT.
- 在PVT和非PVT组之间观察到各种临床和病毒学标记的显著差异.
- 不良的病毒学反应,更大的脏主要轴和更高的HBsAg/HBsAb水平与增加的PVT风险有关,即使在PSM分析后.
结论:
- 在CHB肝硬化患者中,PVT是常见的并发症.
- 对抗病毒疗法的有利病毒学反应有助于降低PVT风险.
- 一个预测性名录,包括诸如HCC,病毒学反应,年龄和特定的临床标记等因素,可以预测CHB患者的PVT.
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