代谢生物标志物可能是计时中风发作的分子钟
Qianyun Li1, Xiaodan Zhang1, Yilin Zhang1
1Department of Emergency Medicine, School of Clinical Medicine, LKS Faculty of Medicine, The University of Hong Kong. G06, G/F, University of Hong Kong the Hong Kong Jockey Club Building for Interdisciplinary Research, University of Hong Kong, 5 Sassoon Road, Pokfulam, Hong Kong SAR, China.
Scientific reports
|July 2, 2025
概括
新的代谢生物标志物,比利韦丁和尼古丁胺胺 N-氧化物,可以在4.5小时内确定急性缺血性中风 (AIS) 发病时间. 这可能会延长未知发病时间的患者的治疗机会.
科学领域:
- 生物化学 生物化学
- 神经学 神经学
- 医学诊断 医学诊断 医学诊断
背景情况:
- 急性缺血性中风 (AIS) 治疗,静脉血栓溶解 (IVT),具有从症状发作4.5小时的关键时间窗口.
- 许多AIS患者因不清楚症状发病时间而被排除在IVT之外.
- 确定可靠的生物标志物来确定发病时间对于扩大IVT资格至关重要.
研究的目的:
- 为了确定能够在4.5小时IVT窗口内区分AIS患者的代谢生物标志物.
- 评估这些生物标志物的诊断准确性,以确定AIS发病时间.
- 探索这些生物标志物的潜力,以扩大对未知发病时间的患者的IVT接入.
主要方法:
- 追溯病例控制研究,涉及30名AIS患者.
- 对早期AIS (0-4.5h) 和晚期AIS (4.5-24h) 组的血代谢物概况进行了分析.
- 使用逐步分析来确定区分组的潜在生物标志物.
主要成果:
- 鉴定出比利弗丁和尼古丁胺N-氧化物 (NAMO) 是潜在的生物标志物.
- 比利韦丁和NAMO的组合实现了0.964的曲线下的高面积 (AUC) 来确定发病时间.
- 这种生物标志物小组表现出100%的特异性和93.75%的敏感性,可在4.5小时内识别AIS.
结论:
- 比利维尔丁和NAMO显示出作为确定AIS发病时间的分子时钟的希望.
- 这些生物标志物可能会使未知发病时间的患者能够更广泛地获得IVT.
- 需要在更大,独立的队列中进行进一步的验证,以确认临床适用性和对AIS管理的影响.
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