在低度质瘤中,NMD核心因子UPF1的预后意义
Shuo Yang1, Na Wu1, Yumeng Duan1
1Dali Bai Autonomous Prefecture, Clinical Medicine College of Dali University, Dali Bai Autonomous Prefecture, Dali City, Yunnan Province, China.
Scientific reports
|July 2, 2025
概括
上游框架转移蛋白1 (UPF1) 在儿科低度质瘤 (LGG) 中升高,与瘤入侵和免疫细胞透相关. UPF1显示出预后价值,表明其作为LGG的生物标志物的潜力.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
背景情况:
- 低级质瘤 (LGG) 在儿科患者中很常见,但UPF1在其进展和入侵中的作用尚未完全理解.
- UPF1是无意中介mRNA衰变 (NMD) 的关键因素,这是一个涉及各种癌症的过程.
研究的目的:
- 研究UPF1在低度质瘤中的表达,预后价值和潜在作用.
- 探索UPF1与瘤微环境,免疫透和患者生存之间的关联.
主要方法:
- 通过TCGA和GTEx数据分析LGG组织中的UPF1表达,并通过HPA分析蛋白质水平.
- 进行了基因丰富,基因改变,甲基化,免疫透和临床病理学分析.
- 使用Kaplan-Meier,ROC曲线分析和名图表的发展来评估预后意义.
主要成果:
- 与正常组织相比,LGG组织中的UPF1mRNA和蛋白质水平显著更高.
- UPF1表达与瘤微环境,免疫细胞透 (例如B细胞,CD4+T细胞,巨细胞) 和NMD途径相关.
- 高UPF1表达,高级等级,基因突变,年龄较大和不良治疗与较低的整体存活率 (OS) 有关.
结论:
- UPF1在LGG上调,并作为瘤免疫透和预后的潜在生物标志物.
- UPF1表达,遗传变化和甲基化模式显著影响LGG患者的存活率.
- 纳入UPF1和其他因素的nomogram在预测LGG患者存活率方面表现出中度准确性.
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