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Updated: Sep 17, 2025

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丧失中心度和有效连接性导致叶患者的认知缺陷和抑郁症

Bailing Qin¹, Shujun Su¹, Xuemei Chen¹

¹Department of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.

Scientific reports

|July 2, 2025

概括

(TLE) 由于大脑网络的变化,导致认知和情绪问题. 格兰杰因果分析显示,通过识别这些大脑异常,对诊断TLE有希望.

科学领域:

神经科学是一个神经科学.
医疗成像医学成像
的研究研究.

背景情况:

叶 (TLE) 与显著的神经精神症状和认知缺陷有关.
这些与TLE相关的损伤背后的精确神经生物学机制仍然不完全理解.
识别大脑网络的改变对于理解TLE的影响至关重要.

研究的目的:

用先进的神经成像技术研究TLE患者大脑网络的变化.
为了将神经成像发现与观察到的神经功能症状如抑郁症和认知障碍相关联.
评估特种神经成像分析对TLE的诊断潜力.

主要方法:

休息状态功能磁共振成像 (rsfMRI) 对50名TLE患者和47名健康对照 (HC) 进行.
分析包括中心度 (DC),有效连接 (EC) 和多变量模式分析 (MVPA).
神经心理测试评估了抑郁症和认知功能;格兰杰因果分析 (GCA) 地图用于分类.

主要成果:

与HC患者相比,TLE患者在右下椎中表现出较大的DC,在椎中表现出较低的DC.
在各种大脑区域之间观察到EC的显著变化,包括cuneus,precuneus和occipital gyri.
使用GCA地图的MVPA在TLE检测方面实现了高诊断准确度 (82.47%).

结论:

在TLE的认知和抑郁缺陷与默认模式和视觉网络中的枢纽节点的异常有关.
在TLE患者中,功能连接模式的改变是明显的.
格兰杰因果分析 (GCA) 显示了作为TLE诊断的神经成像生物标志物的潜力.

关键词:

中心性的程度.格兰杰因果关系分析多变量模式分析多变量模式分析时间叶发作时间叶.

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