胰岛素抵抗,认知和功能性大脑网络拓在肥胖的老年人中
Clayton C McIntyre1, Robert G Lyday2, Yixin Su3
1Neuroscience Graduate Program, Wake Forest Graduate School of Arts and Sciences, Winston-Salem, NC, USA.
Scientific reports
|July 2, 2025
概括
在肥胖的老年人中,周围胰岛素抵抗 (PIR) 与较差的执行功能和改变的大脑网络有关. 神经胰岛素信号异常 (NISAs) 显示没有显著的认知或网络关联.
科学领域:
- 神经科学是一个神经科学.
- 代谢健康 代谢健康
- 衰老研究研究 衰老研究
背景情况:
- 肥胖与认知能力下降和大脑变化有关.
- 胰岛素抵抗会影响周围组织和大脑.
- 了解这些关系对于老龄化人口至关重要.
研究的目的:
- 研究周围胰岛素抵抗 (PIR) 和神经胰岛素信号异常 (NISAs) 与肥胖的老年人执行功能和大脑网络拓学的关联.
- 区分PIR和NISA在认知和神经结果中的作用.
主要方法:
- 对71名肥胖的老年人 (没有2型糖尿病) 的横截面研究.
- 使用HOMA2-IR和NISAs使用神经元衍生的细胞外囊泡度量 (R) 量化PIR.
- 评估执行功能,听觉语言学习和休息状态功能磁共振成像 (rs-fMRI) 衍生的大脑网络.
主要成果:
- HOMA2-IR (PIR) 与执行功能有负相关性,但与听觉语言学习测试 (AVLT) 成绩无关.
- HOMA2-IR与海马体网络拓学有关.
- NISAs (R) 没有显示与执行功能,AVLT分数或任何大脑网络拓学的显著关联.
结论:
- 周围胰岛素抵抗与肥胖的老年人中执行功能受损和海马网络拓学的改变有关.
- 测量到的神经胰岛素信号异常,似乎与这个队列的认知功能或大脑网络拓学无关.
- 研究结果强调了新陈代谢健康对大脑衰老和认知的影响.
更多相关视频
08:47Live Images of GLUT4 Protein Trafficking in Mouse Primary Hypothalamic Neurons Using Deconvolution Microscopy
Published on: December 7, 2017
9.9K
08:32Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain
Published on: January 4, 2018
10.4K
相关概念视频
01:30Cognitive Development During Adulthood
299
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
299
01:24Obesity
624
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
624
01:26Aging
193
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
193
01:19Psychoneuroimmunology: Diabetes and Cancer
67
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
67