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血清Tsukushi水平与代谢功能障碍相关的脂肪性肝病中的胆固醇排泄能力有负相关性:一个横截面研究
Sum Lam1, David T W Lui1, Carol H Y Fong1
1Department of Medicine, School of Clinical Medicine, The University of Hong Kong, Pokfulam, Hong Kong.
Scientific reports
|July 2, 2025
概括
提升的 Tsukushi (TSK) 水平与降低 HDL 胆固醇和与代谢功能障碍相关的脂肪性肝病 (MASLD) 患者的 HDL 功能受损有关. 2型糖尿病加剧了这种效应,影响胆固醇平衡.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 心血管研究研究心血管研究
- 代谢综合征是代谢综合征的一种.
背景情况:
- 一种新型肝激素 Tsukushi (TSK) 影响系统胆固醇稳态,并降低动物模型中的高密度脂蛋白胆固醇 (HDL-C).
- 人类的TSK,HDL-C和HDL功能与代谢功能障碍相关的脂肪性肝病 (MASLD) 之间的关联尚不清楚.
研究的目的:
- 调查血清TSK水平,HDL-C和胆固醇排泄能力 (CEC) 之间的关系,这是HDL功能的关键指标,在有和没有MASLD的个体中.
- 确定2型糖尿病 (T2D) 对这些关联的影响.
主要方法:
- 用振动控制的短暂弹性显微镜来评估肝硬度,并在896名受试者中定义MASLD,包括患有T2D的人.
- 使用ELISA量化血清TSK水平,并通过测量巨细胞的胆固醇外流能力 (CEC) 来评估HDL功能.
- 进行了多变量线性回归分析,以确定CEC的独立决定因素.
主要成果:
- 与没有MASLD的人相比,患有MASLD的人的血清TSK水平较高,HDL-C和CEC显著降低.
- 在MASLD患者中,无论糖尿病状态如何,以及在没有MASLD的糖尿病患者中观察到降低的CEC.
- 在MASLD和T2D的受试者中,CEC的最大减少被发现. 确定TSK和HDL-C是CEC的独立决定因素.
结论:
- 血清TSK水平升高与MASLD患者的HDL-C和CEC负相关.
- 在MASLD和TSK升高的背景下,2型糖尿病的存在加剧了HDL功能 (CEC) 的降低.
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