和多基基物质的时间变化及其与2型糖尿病的关联
Vivian Berg1,2, Dolley D Charles3, Sandra Huber4
1Department of Medical Biology, Faculty of Health Sciences, UiT - The Arctic University of Norway, Stakkevollan, P.O Box 6050, 9037, Tromsø, Norway. Vivian.berg@uit.no.
Scientific reports
|July 2, 2025
概括
和多基基物质 (PFAS) 的时间变化与2型糖尿病 (T2DM) 有不同的关联. 某些PFAS水平及其随时间变化与T2DM风险和患病率有关.
科学领域:
- 环境健康 环境健康
- 内分泌学 在内分泌学.
- 流行病学 流行病学
背景情况:
- 和多基基物质 (PFAS) 是持久的环境污染物.
- 以前的研究表明,PFAS暴露与代谢性疾病之间存在联系,包括2型糖尿病 (T2DM).
- 关于PFAS时间变化和T2DM关联的纵向数据有限.
研究的目的:
- 在30年内调查PFAS度的时间变化.
- 在多个时间点检查特定的PFAS和T2DM风险和患病率之间的关联.
- 为了确定PFAS水平的变化是否与T2DM状态有关.
主要方法:
- 嵌套病例控制研究,在30年内重复测量.
- 在五个时间点进行后勤回归来评估PFAS与T2DM的关联.
- 混合线性模型用于评估PFAS变化与T2DM状态之间的关系.
主要成果:
- 在未来的T2DM病例中观察到PFHpA,PFNA,PFHxS和PFHpS的更高的预诊断度.
- 在诊断后,PFNA和PFOS在流行T2DM病例中较高.
- PFHxS和PFHpS显示出与未来T2DM的积极关联,而PFTrDA则有相反的关联.
- T2DM病例在PFHpA,PFTrDA,PFHxS和PFOSA的诊断前增加更大,在PFOSA的诊断后减少更大.
结论:
- 特定PFAS的时间变化与T2DM状态有关.
- 根据特定的PFAS和采样年份,PFAS和T2DM之间的关联有所不同.
- 这项研究为PFAS暴露与T2DM发展和进展之间的动态关系提供了新的见解.
相关概念视频
Diabetes Mellitus: Type 2 and Gestational
3.0K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
3.0K
Diabetes: Symptoms, Diagnosis, and Complications
706
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
706
Pathophysiology of Diabetes
1.2K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
1.2K
Psychoneuroimmunology: Diabetes and Cancer
67
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
67
Oral Hypoglycemic Agents: Biguanides and Glitazones
309
Biguanides, particularly metformin (Glucophage), are insulin sensitizers that enhance glucose uptake, thereby reducing insulin resistance. Unlike sulfonylureas, metformin doesn't prompt insulin secretion, which helps to curb hypoglycemia risk. Metformin is beneficial in treating conditions like polycystic ovary syndrome due to its insulin-resistance reduction capability. The drug's primary action involves curtailing hepatic gluconeogenesis, a significant contributor to high blood...
309
Carbohydrate Metabolism
11.8K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
11.8K


