血小板与高密度脂蛋白胆固醇的比率与甲状腺激素异常有关,基于NHANES 2007年至2012年的数据
1Department of Thyroid Surgery, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, No. 238 Tongzipo Road, Changsha, 410013, Hunan, China.
Scientific reports
|July 2, 2025
概括
血小板/高密度脂蛋白胆固醇 (PHR) 的比率与甲状腺激素水平和甲状腺功能低下有关. 较高的PHR可能表明FT3,TT4升高,甲状腺功能低下的风险增加.
科学领域:
- 内分泌学 在内分泌学.
- 临床生物化学 临床生物化学
- 公共卫生 公共卫生
背景情况:
- 甲状腺激素异常与代谢和心血管疾病有关.
- 甲状腺功能障碍的可获得预测因素有限.
- 血小板/高密度脂蛋白胆固醇比率 (PHR) 是一个易于获得的生物标志物.
研究的目的:
- 调查PHR与甲状腺激素水平 (FT3,FT4,TT4) 之间的关联.
- 探索PHR与甲状腺功能低下症的流行之间的关系.
- 评估PHR作为甲状腺功能障碍的潜在预测因素.
主要方法:
- 分析国家健康和营养检查调查 (NHANES) 数据 (2007-2012) 来自8440名参与者.
- 使用了加权多重线性和逻辑回归模型.
- 进行了子组,平滑曲线和值效应分析.
主要成果:
- 较高的PHR四分位数与FT3,TT4升高,甲状腺功能低下的患病率增加有关.
- 在调整后,PHR与FT3和TT4有显著的正相关性,与FT4/FT3和FT4/TT4比率有负相关性.
- 观察到非线性关联,FT3和TT4的拐点为FT3.
结论:
- PHR与FT3,TT4和甲状腺功能低下的患病率显著相关.
- PHR可以作为一个有希望的,可访问的标志物来预测甲状腺激素异常.
- 这些发现特别适用于资源有限的环境,缺乏常规甲状腺查.
相关概念视频
01:20Synthesis and Regulation of Thyroid Hormones
5.2K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
5.2K
01:25Blood Studies for Cardiovascular System III: Serum Lipid Profile
298
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
298
01:18Functions of Thyroid Hormones
3.2K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
3.2K