晚期生殖年龄AMH的预测价值:一个回顾性队列研究
Nejc Kozar1,2, Vida Gavrić Lovrec3,4, Borut Kovačič3
1Department of Reproductive Medicine and Gynaecological Endocrinology, University Medical Centre Maribor, Ljubljanska ulica 5, 2000, Maribor, Slovenia. nejc.kozar@ukc-mb.si.
Scientific reports
|July 2, 2025
概括
抗穆勒尔激素 (AMH) 水平预测了医疗辅助生殖 (MAR) 中的临床怀孕. 它的预测价值随着年龄的增长而增加,特别是在35岁以上的女性中,有助于评估生育能力.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 不孕症研究 不孕症研究
- 临床产科和妇科 临床产科和妇科
背景情况:
- 抗穆勒激素 (AMH) 是卵巢储备的一个关键生物标志物,由粒状细胞产生.
- 医疗辅助生殖 (MAR) 的成功受到各种患者因素的影响,包括年龄和卵巢储备.
- 评估生育潜力,特别是在老年妇女中,需要准确的预测标记.
研究的目的:
- 评估抗米勒尔激素 (AMH) 水平对医疗辅助生殖 (MAR) 中临床妊娠结果的预测能力.
- 专门研究晚期生殖年龄妇女中AMH的年龄依赖预测值.
- 确定AMH与患者年龄相结合的实用性,以优化MAR治疗策略.
主要方法:
- 对4891个MAR周期的回顾性队列分析.
- 在AMH水平和临床怀孕率之间的统计相关性分析.
- 使用曲线下面面积 (AUC) 值对AMH预测性能的年龄特定评估.
主要成果:
- 亚美水平与临床妊娠结果有显著的相关性 (p < 0.01).
- 在35岁以上的女性中,AMH表现出显著的预测价值,随着年龄的增长,准确性增加 (AUC = 0.62-0.69).
- 在年轻女性中,AMH的预测性能不那么明显 (AUC = 0.48-0.53).
结论:
- AMH是MAR成功的一个有价值的预测指标,特别是在后期生殖年龄的妇女身上.
- 将AMH测量与时间年龄相结合,对于准确评估生育潜力至关重要.
- 这些发现支持个性化的MAR治疗方法,特别是对于接近生殖寿命末期的女性.
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