对糖尿病介导的GGT与HDL比率和老年人认知功能的横截面研究
Ye Wang1,2, Yanping Mao2, Tianmei Xu1
1The Second Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, 310053, China.
Scientific reports
|July 2, 2025
概括
较高的高密度脂蛋白 (HDL) 与高密度脂蛋白转移酶 (GGT) 的比率与美国老年人的认知功能较差有关. 糖尿病在这种关联中发挥着关键作用,突出了潜在的认知衰退途径.
科学领域:
- 公共卫生 公共卫生
- 神经科学是一个神经科学.
- 代谢综合征是代谢综合征的一种.
背景情况:
- 认知障碍是一个日益严重的全球公共卫生问题.
- 高密度脂蛋白 (HDL) 比率与高密度脂蛋白 (HDL) 比率,与胰岛素抵抗相关的标记物和认知功能之间的关系仍然不清楚.
- 了解影响认知衰退的因素对于开发有针对性的干预措施至关重要.
研究的目的:
- 调查GGT/HDL比率与认知功能之间的关联,特别是使用数字符号替换测试 (DSST).
- 检查糖尿病在GGT/HDL比率与认知表现之间的关系中的潜在调解作用.
- 分析美国代表性人口中的剂量反应关系和子组效应.
主要方法:
- 采用国家健康和营养检查调查 (NHANES) 数据的横截面研究.
- 对2750名参与者进行了加权线性回归和中介分析.
- 使用DSST评估认知能力,并对相关共变量进行统计调整.
主要成果:
- 更高的GGT/HDL比率与较低的DSST得分显著相关,表明认知功能较差 (β = -0.06,P < 0.001).
- 糖尿病被确定为一个显著的调解因子,解释了GGT/HDL比率和DSST得分之间的总影响的13.8% (P = 0.034).
- 没有观察到有意义的非线性关系 (P = 0.169).
结论:
- 在60岁及以上的美国成年人中,高GGT/HDL比率与认知能力下降的风险增加有关.
- 糖尿病显著调解了GGT/HDL比率与认知表现之间的联系.
- 这些发现强调了代谢健康在维持认知功能的重要性,并表明了预防认知障碍的潜在治疗目标.
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