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氧化应激对与多发性硬化症相关的症状的影响
Raquel Piñar-Morales1,2, Raquel Durán3,4,5, Alicia Bautista-García4,5
1Neurology Department, Hospital Universitario Clinico San Cecilio, Granada, Spain. rpinarmorales@gmail.com.
Scientific reports
|July 2, 2025
概括
氧化应激标记在多发性硬化症 (MS) 中发生变化. 在MS患者中,较低的抗氧化能力和更高的特定氧化损伤指标表明它在疾病的发病和进展中发挥了作用.
科学领域:
- 神经科学是一个神经科学.
- 生物化学 生物化学
- 免疫学 免疫学 免疫学
背景情况:
- 多发性硬化症 (MS) 是一种慢性中枢神经系统疾病,病理生理学不明.
- 氧化应激与MS炎症和神经退行有关.
研究的目的:
- 与健康对照组相比,分析患有多发性硬化症 (pwMS) 患者的氧化应激参数.
- 调查氧化应激标志物与MS疾病活动,持续时间和认知功能之间的关系.
主要方法:
- 测量了超氧化物脱酶 (SOD) 活性,总抗氧化能力 (TAC),4-氧诺纳尔 (4-HNE) 和8-氧-2'-脱氧氨酸 (8-OHdG).
- 与临床数据相关联的氧化应激标志物,MRI损伤负担和认知处理速度.
主要成果:
- 与对照组相比,pwMS的SOD活性较高,但TAC,4-HNE和8-OHdG较低.
- 与年龄和疾病持续时间相关的TAC.
- 与T2-FLAIR病变负担相关的SOD水平,以及与年度复发率相关的8-OHdG.
- 较低的TAC和更高的4-HNE与pwMS中的处理速度较慢有关.
结论:
- 氧化应激标志物在多发性硬化症中显著改变,将其与疾病发病因子联系起来.
- 特定的氧化应激参数与MS疾病活性和认知障碍相关.
- 氧化应激标志物与抑郁症,疲劳或生活质量之间没有发现任何关联.
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