预后营养指数对老年关节骨折患者死亡率的值效应
Peng Yang1, Lin Liu1, Zhi Yang1
1Department of Joint Surgery, Honghui Hospital, Xi'an Jiaotong University, No. 555 Youyi East Road, Xi'an, Shaanxi Province, China.
Scientific reports
|July 2, 2025
概括
预后营养指数 (PNI) 是老年关节骨折患者死亡率的关键预测指标. 低于50.3的PNI显著降低死亡风险,然后稳定下来.
科学领域:
- 老年医学 老年医学
- 外科手术的结果
- 营养科学 营养科学
背景情况:
- 关节骨折是老年人患病和死亡的一个重要原因.
- 准确的风险分层对于优化关节骨折手术后的患者结果至关重要.
- 预后营养指数 (PNI) 是评估营养状况和预测结果的潜在生物标志物.
研究的目的:
- 为了研究预后营养指数 (PNI) 与患有部骨折的老年患者的术后死亡率之间的非线性关联.
- 为了确定与死亡风险有关的PNI的潜在转折点.
- 确定PNI在此患者组的手术前风险分层中的临床实用性.
主要方法:
- 一项对2115名老年关节骨折患者 (2015年1月 - 2019年9月) 的回顾性研究.
- 收集人口统计数据和生存跟踪.
- 应用多变量考克斯比例危险回归和受限立方线来分析PNI和死亡率之间的线性和非线性关联.
- 两部分的考克斯回归模型来确定拐点.
主要成果:
- 一个线性关联表明PNI与死亡率相关 (HR=0.95).
- 非线性分析显示,PNI = 50.3.3 的拐点是 50.3.
- 在50.3以下,PNI每增加1个单位,死亡率降低6% (HR=0.94).
- 在50.3以上,PNI与死亡率没有显著关联 (HR=1.03),死亡率稳定.
结论:
- 预后营养指数 (PNI) 显示,在老年骨折患者中,与死亡率存在显著的非线性关联.
- 50.3的PNI门作为一个关键的拐点,区分风险水平.
- 建议在老年关节骨折患者的手术前风险分层中进行PNI评估,注意其在此门以下的预测值.
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