血清CA72-4升高作为急性痛风爆发的新型诊断生物标志物
Yong Zhuang1, Xin Hu1, Qingyan Cai1
1Department of Endocrinology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, 362000, China.
Scientific reports
|July 2, 2025
概括
在痛风爆发期间,糖抗原724 (CA72-4) 水平显著升高,超过C反应蛋白 (CRP) 作为诊断标志物. 胆固醇治疗进一步增加了痛风患者的CA72-4水平.
科学领域:
- 类风湿病学 类风湿病学
- 临床化学 临床化学
- 生物标志物研究 生物标志物研究
背景情况:
- 葡萄糖抗原724 (CA72-4) 是一个已知的瘤标志物.
- 它在痛风中的作用,特别是在爆发和治疗期间,尚不清楚.
研究的目的:
- 为了研究不同疾病阶段的痛风患者的CA72-4表达.
- 为了评估CA72-4水平的变化,在科尔奇辛治疗后.
- 为了比较CA72-4和CRP对于痛风发作的诊断值.
主要方法:
- 观察性临床研究,比较痛风患者 (发病与没有发病) 和健康对照.
- 测量了血清CA72-4和其他瘤标志物 (CA12-5,CA19-9,CEA).
- 使用ROC曲线分析来评估诊断性能.
- 痛风发作小组接受了胆固醇或没有胆固醇.
主要成果:
- 与非发作和对照组相比,痛风发作中的血清CA72-4水平显著更高.
- 升高的CA72-4,CRP,BMI和tophi是急性痛风发作的独立预测因素.
- 在痛风发作中,CA72-4显示出更高的诊断准确性 (AUC=0.966) 与CRP (AUC=0.900) 相比.
- 胆固醇治疗与痛风爆发期间血清CA72-4进一步升高有关.
结论:
- 血清CA72-4是急性痛风爆发的有前途的诊断标志物,准确度高于CRP.
- 在痛风爆发时,CA72-4水平升高,并且在接受胆固醇治疗时进一步增加.
- 其他瘤标志物在两组之间没有显著差异.
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