在患有三角神经疼痛的患者中,岛内皮层的异常静态和动态功能连接性异常
Yuying Chen1,2, Shumei Li2, Meng Li2
1Guangdong Medical University, Zhanjiang, People's Republic of China.
Scientific reports
|July 2, 2025
概括
三神经疼痛 (TN) 患者在岛内皮层表现出改变的静态和动态功能连接 (sFC和dFC). 这些大脑连接的变化与疼痛的严重程度和持续时间有关,突出了它们在TN机制中的作用.
科学领域:
- 神经科学是一个神经科学.
- 医疗成像医学成像
- 临床神经学 临床神经学
背景情况:
- 三神经疼痛 (TN) 是一种慢性疼痛疾病,其特征是面部疼痛.
- 在TN病理生理学中异常岛皮功能连接 (sFC和dFC) 的作用仍然不清楚.
研究的目的:
- 为了研究TN患者岛内皮层 (IC) 静态和动态功能连接 (sFC和dFC) 的变化.
- 探索IC功能连接性改变和TN的临床措施之间的关系.
主要方法:
- 休息状态功能磁共振成像 (rs-fMRI) 用于40名TN患者和30名健康对照 (HCs).
- 在双边IC上进行了基于voxel的sFC和dFC分析.
- 两个样本的t测试确定了群体差异,Pearson相关性检查了与临床数据 (VAS,情绪,疼痛持续时间) 的关联.
主要成果:
- 在TN患者中,双边IC和多个大脑区域之间的sFC显著降低,包括右上旋,左罗兰 operculum,左thalamus,左上边旋和左上旋.
- 与HC患者相比,TN患者在IC和小脑虫之间观察到DCF降低.
- 在IC-thalamus sFC和疼痛强度 (VAS) 之间,以及在IC-vermis dFC和疼痛持续时间之间发现了负相关性.
结论:
- 异常的静态和动态功能连接涉及岛屿皮层和其他大脑区域是特征的TN.
- 这些连接性改变与疼痛严重程度和持续时间的临床测量有关.
- 这些发现表明,改变的岛屿功能连接在三角神经疼痛背后的神经机制中起着关键作用.
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